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Antibody and antigen target The antibody component of ADCs is predominantly humanized, being the IgG 1 class the predominant antibody backbone [6], given its extended serum half-life and Fcreceptor (FcR)binding affinity associated with complement-mediated cytotoxicity and antibody-dependent cellular cytotoxicity [7]

PMID 9367343

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These types of inhibitors may exhibit better inhibitory effects